Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925177 | 1.00 | HSD11B1 (0.38) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL19925167 | 0.89 | HSD11B1 (0.41) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL29464409 | 0.89 | HSD11B1 (0.41) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL29464528 | 0.89 | HSD11B1 (0.40) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL19925697 | 0.89 | HSD11B1 (0.40) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL19925085 | 0.88 | HSD11B1 (0.36) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL29464474 | 0.88 | HSD11B1 (0.36) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL19968776 | 0.87 | L3MBTL1 (0.36) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL29464513 | 0.87 | L3MBTL1 (0.36) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL19927731 | 0.87 | HSD11B1 (0.36) | HSD11B1L3MBTL1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |