Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | SCN1A | P35498 | 7/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925085 | 1.00 | HSD11B1 (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL29464491 | 0.93 | HSD11B1 (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL19925075 | 0.93 | HSD11B1 (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL19925697 | 0.92 | HSD11B1 (0.40) | HSD11B1L3MBTL1FBP1PKMKDM4E | |
| SCHEMBL29464528 | 0.92 | HSD11B1 (0.40) | HSD11B1L3MBTL1FBP1PKMKDM4E | |
| SCHEMBL19925119 | 0.91 | PKM (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL29464480 | 0.91 | PKM (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL29464513 | 0.90 | L3MBTL1 (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL19968776 | 0.90 | L3MBTL1 (0.36) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL19925167 | 0.90 | HSD11B1 (0.41) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |