Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19927753 | 1.00 | EDNRA (0.38) | EDNRAHTTHSD11B1ALDH1A1L3MBTL1 | |
| SCHEMBL29464461 | 0.90 | EDNRA (0.36) | EDNRAHTTHSD11B1ALDH1A1L3MBTL1 | |
| SCHEMBL19928756 | 0.90 | EDNRA (0.36) | EDNRAHTTHSD11B1ALDH1A1L3MBTL1 | |
| SCHEMBL19925697 | 0.86 | HSD11B1 (0.40) | HTTHSD11B1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL29464528 | 0.86 | HSD11B1 (0.40) | HTTHSD11B1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL19968767 | 0.85 | HSD11B1 (0.39) | HSD11B1ALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL29464483 | 0.85 | HSD11B1 (0.39) | HSD11B1ALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL29464411 | 0.83 | ALDH1A1 (0.41) | HSD11B1ALDH1A1L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL19925181 | 0.83 | ALDH1A1 (0.41) | HSD11B1ALDH1A1L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL29464347 | 0.82 | HSD11B1 (0.39) | HTTHSD11B1ALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |