Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 9/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | RORB | Q92753 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925398 | 1.00 | KIF18A (0.33) | KIF18ADGAT1KCNH2JAK2KMO | |
| SCHEMBL19925396 | 1.00 | KIF18A (0.33) | KIF18ADGAT1KCNH2JAK2KMO | |
| SCHEMBL19951306 | 0.93 | DGAT1 (0.34) | KIF18ADGAT1KCNH2JAK2KMO | |
| SCHEMBL29464518 | 0.93 | DGAT1 (0.34) | KIF18ADGAT1KCNH2JAK2KMO | |
| SCHEMBL19951305 | 0.93 | DGAT1 (0.34) | KIF18ADGAT1KCNH2JAK2KMO | |
| SCHEMBL19925808 | 0.92 | CTSA (0.34) | KIF18ADGAT1KCNH2CYP1A2CYP2D6 | |
| SCHEMBL19925805 | 0.92 | CTSA (0.34) | KIF18ADGAT1KCNH2CYP1A2CYP2D6 | |
| SCHEMBL29464511 | 0.92 | CTSA (0.34) | KIF18ADGAT1KCNH2CYP1A2CYP2D6 | |
| SCHEMBL19925715 | 0.91 | RORC (0.32) | KIF18ADGAT1KCNH2RORCRORB | |
| SCHEMBL19925709 | 0.91 | RORC (0.32) | KIF18ADGAT1KCNH2RORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |