Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.38 |
| ▸ | ITGAL | P20701 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925097 | 1.00 | HSD11B1 (0.39) | HSD11B1SYKIDH2ITGB2ICAM1 | |
| SCHEMBL19925142 | 1.00 | HSD11B1 (0.39) | HSD11B1SYKIDH2ITGB2ICAM1 | |
| SCHEMBL29464453 | 1.00 | HSD11B1 (0.39) | HSD11B1SYKIDH2ITGB2ICAM1 | |
| SCHEMBL19925286 | 0.96 | HSD11B1 (0.43) | HSD11B1MPLWDR5NOTUM | |
| SCHEMBL29464449 | 0.96 | HSD11B1 (0.43) | HSD11B1MPLWDR5NOTUM | |
| SCHEMBL29464420 | 0.91 | IDH2 (0.39) | SYKIDH2ITGB2ICAM1ITGAL | |
| SCHEMBL29464498 | 0.91 | IDH2 (0.39) | SYKIDH2ITGB2ICAM1ITGAL | |
| SCHEMBL19951391 | 0.91 | IDH2 (0.39) | SYKIDH2ITGB2ICAM1ITGAL | |
| SCHEMBL19925047 | 0.91 | IDH2 (0.39) | SYKIDH2ITGB2ICAM1ITGAL | |
| SCHEMBL23651293 | 0.90 | FFAR2 (0.38) | HSD11B1SYKKDM4EWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |