Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.40 |
| ▸ | MPL | P40238 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925286 | 1.00 | HSD11B1 (0.43) | HSD11B1NOTUMMPLRORCKEAP1 | |
| SCHEMBL19925097 | 0.96 | HSD11B1 (0.39) | HSD11B1NOTUMMPLWDR5 | |
| SCHEMBL19925142 | 0.96 | HSD11B1 (0.39) | HSD11B1NOTUMMPLWDR5 | |
| SCHEMBL29464447 | 0.96 | HSD11B1 (0.39) | HSD11B1NOTUMMPLWDR5 | |
| SCHEMBL29464453 | 0.96 | HSD11B1 (0.39) | HSD11B1NOTUMMPLWDR5 | |
| SCHEMBL29464392 | 0.91 | NOTUM (0.40) | HSD11B1NOTUMMPLRORCKEAP1 | |
| SCHEMBL29464440 | 0.91 | NOTUM (0.40) | HSD11B1NOTUMMPLRORCKEAP1 | |
| SCHEMBL19925204 | 0.91 | NOTUM (0.40) | HSD11B1NOTUMMPLRORCKEAP1 | |
| SCHEMBL19925098 | 0.91 | NOTUM (0.40) | HSD11B1NOTUMMPLRORCKEAP1 | |
| SCHEMBL23651293 | 0.87 | FFAR2 (0.38) | HSD11B1WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |