SCHEMBL29464822

SCHEMBL29464822

COc1c(-c2ccc(C(F)(F)F)c3c2CCCS3)cnn(C)c1=O

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LRRK2 Q5S007 4/20 0.34
CYP26A1 O43174 1/20 0.31
CYP24A1 Q07973 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
GRM2 Q14416 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23152444 1.00 LRRK2 (0.34) LRRK2CYP26A1CYP24A1ALDH1A1HPGD
SCHEMBL29464811 0.79 LRRK2 (0.34) LRRK2ALDH1A1HPGDGRM2
SCHEMBL23178072 0.79 LRRK2 (0.34) LRRK2ALDH1A1HPGDGRM2
SCHEMBL27083028 0.78 LRRK2 (0.33) LRRK2
SCHEMBL16716785 0.72 ALDH1A1 (0.37) LRRK2ALDH1A1HPGD
SCHEMBL23152443 0.71 PRMT5 (0.32)
SCHEMBL16716787 0.70 ALDH1A1 (0.36) LRRK2ALDH1A1HPGD
SCHEMBL14844488 0.69 RAB9A (0.39) LRRK2ALDH1A1HPGD
SCHEMBL16716788 0.69 ALDH1A1 (0.35) LRRK2ALDH1A1HPGD
SCHEMBL14844550 0.68 ALDH1A1 (0.36) LRRK2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114375292-A 7-oxa-3,4-diazabicyclo [4.1.0] hept-4-en-2-one compounds and herbicides 日本曹达株式会社 2022-04-19 CN disclosed