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SCHEMBL29464873

SCHEMBL29464873

Cc1ccccc1-c1nc(NS(=O)(=O)c2cccc(N3CCC[C@@](C)(C(=O)O)C3)n2)ccc1C1CC1

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 1/20 0.32
▸ RORB Q92753 1/20 0.32
▸ KIF18A Q8NI77 5/20 0.32
▸ CNR2 P34972 1/20 0.31
▸ PTGES O14684 1/20 0.30
▸ DGAT1 O75907 1/20 0.30
▸ KCNH2 Q12809 1/20 0.30
▸ AKT1 P31749 1/20 0.30
▸ MMP2 P08253 1/20 0.30
▸ MMP13 P45452 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19925285 1.00 RORC (0.32) RORCRORBKIF18ACNR2PTGES
SCHEMBL19925284 1.00 RORC (0.32) RORCRORBKIF18ACNR2PTGES
SCHEMBL19951441 0.94 RORC (0.33) RORCRORBKIF18ACNR2DGAT1
SCHEMBL19951440 0.94 RORC (0.33) RORCRORBKIF18ACNR2DGAT1
SCHEMBL19925709 0.92 RORC (0.32) RORCRORBKIF18ACNR2DGAT1
SCHEMBL29464456 0.92 RORC (0.32) RORCRORBKIF18ACNR2DGAT1
SCHEMBL19925715 0.92 RORC (0.32) RORCRORBKIF18ACNR2DGAT1
SCHEMBL19925396 0.91 KIF18A (0.33) RORCRORBKIF18ADGAT1KCNH2
SCHEMBL19925398 0.91 KIF18A (0.33) RORCRORBKIF18ADGAT1KCNH2
SCHEMBL29464342 0.91 KIF18A (0.33) RORCRORBKIF18ADGAT1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109641873-B N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease 诺华股份有限公司 2022-03-18 — — CN disclosed