Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PRKX | P51817 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2631905 | 1.00 | PIM1 (0.38) | PIM1PIM2LMNAMEN1POLB | |
| SCHEMBL19153212 | 0.78 | CCR1 (0.40) | LMNAMEN1POLBKMT2APARP1 | |
| SCHEMBL19130906 | 0.74 | PDE2A (0.36) | LMNAMEN1POLBKMT2AKDM4E | |
| SCHEMBL325051 | 0.73 | PSMD14 (0.47) | LMNAKDM4EPARP1DPP4 | |
| SCHEMBL29804853 | 0.72 | KDM4E (0.53) | LMNAKDM4EMAPK14SIRT2DPP4 | |
| SCHEMBL2105191 | 0.72 | KDM4E (0.53) | LMNAKDM4EMAPK14SIRT2DPP4 | |
| SCHEMBL31114004 | 0.72 | ALDH1A1 (0.43) | KMT2AKDM4EDYRK1ACDK9CDK5 | |
| SCHEMBL669572 | 0.70 | PARP1 (0.50) | PIM1PIM2KDM4EPARP1AURKA | |
| SCHEMBL1477486 | 0.70 | ALDH1A1 (0.41) | PIM1PIM2LMNAPARP1SIRT2 | |
| SCHEMBL29434701 | 0.70 | PARP1 (0.50) | PIM1PIM2KDM4EPARP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852118-A | Compounds that inhibit tyrosine kinase activity and pharmaceutical compositions comprising the same | 德州大学系统董事会 | 2024-10-29 | — | — | CN | disclosed |
| CN-114026083-B | Heterocyclic inhibitors of tyrosine kinases | 德州大学系统董事会 | 2024-07-09 | — | — | CN | disclosed |
| EP-3962908-A1 | HETEROCYCLIC INHIBITORS OF TYROSINE KINASE | Board of Regents, The University of Texas System (US) | 2022-03-09 | — | — | EP | disclosed |