Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PRKX | P51817 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29465797 | 1.00 | PIM1 (0.38) | PIM1PIM2LMNAMEN1POLB | |
| SCHEMBL19153212 | 0.78 | CCR1 (0.40) | LMNAMEN1POLBKMT2APARP1 | |
| SCHEMBL19130906 | 0.74 | PDE2A (0.36) | LMNAMEN1POLBKMT2AKDM4E | |
| SCHEMBL325051 | 0.73 | PSMD14 (0.47) | LMNAKDM4EPARP1DPP4 | |
| SCHEMBL29804853 | 0.72 | KDM4E (0.53) | LMNAKDM4EMAPK14SIRT2DPP4 | |
| SCHEMBL2105191 | 0.72 | KDM4E (0.53) | LMNAKDM4EMAPK14SIRT2DPP4 | |
| SCHEMBL31114004 | 0.72 | ALDH1A1 (0.43) | KMT2AKDM4EDYRK1ACDK9CDK5 | |
| SCHEMBL669572 | 0.70 | PARP1 (0.50) | PIM1PIM2KDM4EPARP1AURKA | |
| SCHEMBL1477486 | 0.70 | ALDH1A1 (0.41) | PIM1PIM2LMNAPARP1SIRT2 | |
| SCHEMBL29434701 | 0.70 | PARP1 (0.50) | PIM1PIM2KDM4EPARP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026083-B | Heterocyclic inhibitors of tyrosine kinases | 德州大学系统董事会 | 2024-07-09 | — | — | CN | disclosed |
| US-11365189-B2 | Heterocyclic inhibitors of tyrosine kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-06-21 | — | — | US | disclosed |
| CN-114026083-A | Heterocyclic inhibitors of tyrosine kinases | 德州大学系统董事会 | 2022-02-08 | — | — | CN | disclosed |
| CN-110903286-B | 4, 6-disubstituted pyridine [3,2-d ] pyrimidine compound and preparation and application thereof | 沈阳药科大学 | 2021-09-24 | — | — | CN | disclosed |
| US-20200354343-A1 | HETEROCYCLIC INHIBITORS OF TYROSINE KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2020-11-12 | — | — | US | disclosed |
| WO-2020219904-A1 | HETEROCYCLIC INHIBITORS OF TYROSINE KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-10-29 | — | — | WO | disclosed |
| CN-110903286-A | 4, 6-disubstituted pyridine [3,2-d ] pyrimidine compound and preparation and application thereof | 沈阳药科大学 | 2020-03-24 | — | — | CN | disclosed |
| EP-2560967-B1 | Heterocyclic carboxylic acid amides as PDK1 inihibitors | BOEHRINGER INGELHEIM INT (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-9422298-B2 | Pyridopyrimidine derivatives and use thereof | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-08-23 | — | — | US | disclosed |
| US-9422298-B2 | Pyridopyrimidine derivatives and use thereof | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-08-23 | — | — | US | disclosed |
| US-20120238587-A1 | NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND USE THEREOF | CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD. (KR) | 2012-09-20 | — | — | US | disclosed |
| US-20120238587-A1 | NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND USE THEREOF | CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD. (KR) | 2012-09-20 | — | — | US | disclosed |
| US-20120238587-A1 | NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND USE THEREOF | CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD. (KR) | 2012-09-20 | — | — | US | disclosed |
| US-20120094976-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| US-7799772-B2 | tyrosine kinase inhibitors such as 7H,19H-4,6-ethanediylidenepyrimido[4,5-b][13,1,4,6]benzoxatriazacyclopentadecine, 17-chloro-8,9,10,11,12,13-hexahydro, used for treating hyper proliferative disorders such as atherosclerosis, restenosis and cancer | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-21 | — | — | US | disclosed |
| EP-2217590-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-08-18 | — | — | EP | disclosed |
| US-20100204222-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS P13 KINASE INHIBITORS | GlaxoSmithKline, LLC | 2010-08-12 | — | — | US | disclosed |
| US-20100173913-A1 | PYRIDO-AND PYRIMIDOPYRIMIDINE DERIVATIVES AS ANTI-PROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-07-08 | — | — | US | disclosed |
| WO-2009039140-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |
| US-20070078132-A1 | tyrosine kinase inhibitors such as 7H,19H-4,6-ethanediylidenepyrimido[4,5-b][13,1,4,6]benzoxatriazacyclopentadecine, 17-chloro-8,9,10,11,12,13-hexahydro, used for treating hyper proliferative disorders such as atherosclerosis, restenosis and cancer | JANSSEN-CILAG (FR) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078132-A1 | tyrosine kinase inhibitors such as 7H,19H-4,6-ethanediylidenepyrimido[4,5-b][13,1,4,6]benzoxatriazacyclopentadecine, 17-chloro-8,9,10,11,12,13-hexahydro, used for treating hyper proliferative disorders such as atherosclerosis, restenosis and cancer | NR1H3, NR1H2, ERBB2 | PIM1 3269/4885PIM2 2946/4885LMNA 3347/4885 |
| US-20120094976-A1 | NEW CHEMICAL COMPOUNDS | CCNB1, MKI67, CCNA1 | PIM1 1699/4885PIM2 2808/4885LMNA 1174/4885 |
| US-20120238587-A1 | NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND USE THEREOF | PIK3CA, PIK3CD, PI4KA | PIM1 775/4885PIM2 1107/4885LMNA 3777/4885 |
| US-20100204222-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS P13 KINASE INHIBITORS | PI4KA, PIK3CA, PFKP | PIM1 612/4885PIM2 742/4885LMNA 4648/4885 |
| US-20200354343-A1 | HETEROCYCLIC INHIBITORS OF TYROSINE KINASE | ERBB2, ERBB3, EGFR | PIM1 511/4885PIM2 442/4885LMNA 4291/4885 |
| US-11365189-B2 | Heterocyclic inhibitors of tyrosine kinase | ERBB2, ERBB3, EGFR | PIM1 511/4885PIM2 442/4885LMNA 4291/4885 |
| US-20100173913-A1 | PYRIDO-AND PYRIMIDOPYRIMIDINE DERIVATIVES AS ANTI-PROLIFERATIVE AGENTS | CYP2J2, NR4A1, ALOX15 | PIM1 4457/4885PIM2 4242/4885LMNA 3006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.