Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12939934 | 0.82 | MAPT (0.58) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL10036155 | 0.81 | SIRT6 (0.63) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL25170783 | 0.79 | MAPT (0.54) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL4507720 | 0.79 | SIRT6 (0.65) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL17630781 | 0.78 | MAPT (0.53) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL10036164 | 0.78 | SIRT6 (0.58) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL29045756 | 0.78 | SIRT6 (0.58) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL29723778 | 0.78 | SIRT6 (0.58) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL14060301 | 0.77 | AKR1C3 (0.49) | MAPTSIRT6ALDH1A1POLBADRB1 | |
| SCHEMBL30307829 | 0.77 | HTR7 (0.40) | MAPTADRB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114195780-A | Carbonyl heterocyclic compound and application thereof | 上海医药集团股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114195806-A | Carbonyl heterocyclic compound and application thereof | 上海医药集团股份有限公司 | 2022-03-18 | — | — | CN | disclosed |