Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28707994 | 1.00 | GPR119 (0.42) | GPR119KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL29467161 | 0.86 | KDM1A (0.43) | GPR119HPGDSMN1; SMN2SCDTP53 | |
| SCHEMBL28714232 | 0.86 | KDM1A (0.43) | GPR119HPGDSMN1; SMN2SCDTP53 | |
| SCHEMBL29467141 | 0.86 | MAOB (0.42) | L3MBTL1SCDMAOB | |
| SCHEMBL28716139 | 0.86 | MAOB (0.42) | L3MBTL1SCDMAOB | |
| SCHEMBL28719227 | 0.85 | SCD (0.43) | KDM4ESMN1; SMN2SCDTP53ALKBH1 | |
| SCHEMBL29467187 | 0.85 | SCD (0.43) | KDM4ESMN1; SMN2SCDTP53ALKBH1 | |
| SCHEMBL23076353 | 0.85 | KDM1A (0.40) | SMN1; SMN2SCDTP53RIPK1 | |
| SCHEMBL20029212 | 0.84 | SCD (0.47) | SCDRIPK1 | |
| SCHEMBL28707297 | 0.82 | ALKBH1 (0.41) | GPR119SCDALKBH1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206861-A | Fused heteroaryl compounds useful as RIPK1 inhibitors | 比西切姆有限公司 | 2022-03-18 | — | — | CN | disclosed |