Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28694487 | 1.00 | MAPT (0.49) | MAPTMAPK1ALDH1A1NPC1HTT | |
| SCHEMBL28694485 | 1.00 | MAPT (0.49) | MAPTMAPK1ALDH1A1NPC1HTT | |
| SCHEMBL29467204 | 1.00 | MAPT (0.49) | MAPTMAPK1ALDH1A1NPC1HTT | |
| SCHEMBL24689326 | 0.89 | MAPT (0.64) | MAPTMAPK1ALDH1A1NPC1HTT | |
| SCHEMBL30461757 | 0.87 | FPR2 (0.47) | MAPTMAPK1ALDH1A1USP30LMNA | |
| SCHEMBL25273382 | 0.87 | FPR2 (0.47) | MAPTMAPK1ALDH1A1USP30LMNA | |
| SCHEMBL22638389 | 0.86 | KMT2A (0.46) | MAPTMAPK1GFERKMT2APLA2G1B | |
| SCHEMBL22638386 | 0.86 | KMT2A (0.46) | MAPTMAPK1GFERKMT2APLA2G1B | |
| SCHEMBL28694478 | 0.85 | MAPT (0.46) | MAPTMAPK1ALDH1A1L3MBTL1USP30 | |
| SCHEMBL28694480 | 0.85 | MAPT (0.46) | MAPTMAPK1ALDH1A1L3MBTL1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187723-B2 | Substituted benzimidazolone compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-01-07 | — | — | US | disclosed |
| EP-3965888-B1 | SUBSTITUTED BENZIMIDAZOLONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2024-08-21 | — | — | EP | disclosed |
| US-20220289739-A1 | SUBSTITUTED BENZIMIDAZOLONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-09-15 | — | — | US | disclosed |
| EP-3965888-A1 | SUBSTITUTED BENZIMIDAZOLONE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2022-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12187723-B2 | Substituted benzimidazolone compounds | TLR7, TLR1, TLR9 | MAPT 4814/4885MAPK1 210/4885ALDH1A1 988/4885 |
| US-20220289739-A1 | SUBSTITUTED BENZIMIDAZOLONE COMPOUNDS | TLR7, TLR1, TLR9 | MAPT 4814/4885MAPK1 210/4885ALDH1A1 988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.