Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24334422 | 1.00 | ALDH1A1 (0.34) | ALDH1A1RAB9ASMN1; SMN2ATMNPSR1 | |
| SCHEMBL24333653 | 0.87 | ALDH1A1 (0.34) | ALDH1A1RAB9ASMN1; SMN2ATMNPSR1 | |
| SCHEMBL29469685 | 0.87 | ALDH1A1 (0.34) | ALDH1A1RAB9ASMN1; SMN2ATMNPSR1 | |
| SCHEMBL29469619 | 0.85 | RORC (0.34) | ALDH1A1RAB9ASMN1; SMN2ATMNPSR1 | |
| SCHEMBL29469915 | 0.85 | SCN9A (0.34) | RORCMCHR1KCNH2 | |
| SCHEMBL24333336 | 0.85 | SCN9A (0.34) | RORCMCHR1KCNH2 | |
| SCHEMBL24334419 | 0.80 | ALDH1A1 (0.33) | ALDH1A1RAB9ASMN1; SMN2ATMNPSR1 | |
| SCHEMBL29469668 | 0.80 | RXFP1 (0.36) | ALDH1A1RAB9ASMN1; SMN2ATMNPSR1 | |
| SCHEMBL24333413 | 0.80 | RXFP1 (0.34) | ALDH1A1RAB9AATMNPSR1TSHR | |
| SCHEMBL29469659 | 0.80 | RXFP1 (0.34) | ALDH1A1RAB9AATMNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |