Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 4/20 | 0.58 |
| ▸ | CA9 | Q16790 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | ATIC | P31939 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10817165 | 1.00 | NQO2 (0.62) | NQO2CA1CA9CA2LDHA | |
| SCHEMBL669147 | 0.85 | NQO2 (0.55) | NQO2CA1CA9CA2CYP2C9 | |
| SCHEMBL29965723 | 0.85 | NQO2 (0.55) | NQO2CA1CA9CA2MCL1 | |
| SCHEMBL547642 | 0.85 | NQO2 (0.55) | NQO2CA1CA9CA2MCL1 | |
| Ammonia Solution, Strong SCHEMBL7523204 | 0.83 | NQO2 (0.53) | NQO2CA1CA9CA2CYP2C9 | |
| SCHEMBL7859087 | 0.83 | NQO2 (0.53) | NQO2CA1CA9CA2CYP2C9 | |
| Sulfuric Acid SCHEMBL10415586 | 0.81 | NQO2 (0.80) | NQO2CA1CA9CA2LDHA | |
| SCHEMBL7859084 | 0.80 | NQO2 (0.50) | NQO2CA1CA9CA2MCL1 | |
| SCHEMBL4559508 | 0.79 | CA1 (0.60) | CA1CA9CA2LDHAMCL1 | |
| SCHEMBL1807638 | 0.79 | CA2 (0.60) | NQO2CA1CA9CA2LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |