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Lypressin

Lypressin

SCHEMBL29471105

CC(=O)O.NCCCCC(NC(=O)C1CCCN1C(=O)C1CSSCC(N)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(Cc2ccccc2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AVPR1AAVPR1BAVPR2

The experimentally established mechanism targets of Lypressin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ AVPR1A known ✓ P37288 8/20 0.84
▸ AVPR2 known ✓ P30518 6/20 0.84
▸ AVPR1B known ✓ P47901 6/20 0.84
▸ OXTR P30559 10/20 0.84
▸ TBXA2R P21731 1/20 0.80
▸ PDE4D Q08499 1/20 0.80
▸ PDE3A Q14432 1/20 0.80
▸ PTGS1 P23219 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ornipressin SCHEMBL4410141 0.98 AVPR1A (0.85) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Lypressin SCHEMBL33287 0.98 OXTR (0.87) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Lypressin SCHEMBL1650587 0.98 OXTR (0.87) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Felypressin SCHEMBL4405496 0.97 AVPR1A (0.79) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Ornipressin SCHEMBL1650220 0.97 AVPR1A (0.88) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Ornipressin SCHEMBL296322 0.97 AVPR1A (0.88) OXTRAVPR1AAVPR2AVPR1BTBXA2R
SCHEMBL24239052 0.96 OXTR (0.82) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Felypressin SCHEMBL1650172 0.96 AVPR1A (0.82) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Felypressin SCHEMBL361197 0.96 AVPR1A (0.82) OXTRAVPR1AAVPR2AVPR1BTBXA2R
Felypressin SCHEMBL31138866 0.96 AVPR1A (0.82) OXTRAVPR1AAVPR2AVPR1BTBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114556100-A Therapy guidance and/or therapy monitoring for treatment of shock 4TEEN4制药有限公司 2022-05-27 — — CN disclosed
CN-114306250-A Terlipressin acetate preparation and preparation method thereof 苏州天马医药集团天吉生物制药有限公司 2022-04-12 — — CN disclosed
CN-114126619-A Compounds for the synthesis of peptidomimetics 范因斯坦医学研究院 2022-03-01 — — CN disclosed
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