Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 14/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 14/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23347204 | 0.80 | ALOX5AP (0.56) | ALOX5APFEN1STAT3TRPA1 | |
| SCHEMBL3304437 | 0.80 | CYP11B1 (0.72) | CYP11B1CYP11B2TUBB4ATUBBTUBA3C | |
| SCHEMBL14555723 | 0.78 | CYP11B1 (0.68) | CYP11B1CYP11B2ALOX5APFEN1TUBB4A | |
| SCHEMBL8678897 | 0.76 | SYK (0.43) | CYP11B1CYP11B2TUBB4ATUBBTUBA3C | |
| SCHEMBL24989659 | 0.76 | CYP11B1 (0.48) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL9755559 | 0.75 | TSHR (0.49) | CYP11B1CYP11B2TUBB4ATUBBTUBA3C | |
| SCHEMBL9287992 | 0.75 | ALOX5AP (0.50) | ALOX5APFEN1TRPA1 | |
| SCHEMBL2948017 | 0.75 | ALOX5AP (0.54) | ALOX5APFEN1TRPA1 | |
| SCHEMBL21675486 | 0.75 | ALOX5AP (0.42) | ALOX5APFEN1TRPA1 | |
| SCHEMBL19187744 | 0.74 | CYP11B1 (0.54) | CYP11B1CYP11B2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |