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Sugi Predict / Compounds / SCHEMBL29477190

SCHEMBL29477190

SCHEMBL29477190

CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TFPI P10646 6/20 0.61
▸ KDM1A O60341 2/20 0.60
▸ CXCL8 P10145 2/20 0.60
▸ OPRM1 P35372 6/20 0.59
▸ OPRK1 P41145 6/20 0.59
▸ NMUR2 Q9GZQ4 2/20 0.57
▸ NMUR1 Q9HB89 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30176214 0.95 KDM1A (0.60) TFPIKDM1ANMUR2NMUR1
SCHEMBL31415954 0.91 KDM1A (0.56) KDM1AOPRM1OPRK1
SCHEMBL29973025 0.89 APLNR (0.60) OPRM1OPRK1NMUR2NMUR1
SCHEMBL31694497 0.88 CXCR4 (0.64) CXCL8
SCHEMBL30842159 0.88 NMUR2 (0.64) TFPIOPRM1NMUR2NMUR1
SCHEMBL29811013 0.88 F2 (0.57) KDM1ANMUR2NMUR1
SCHEMBL30842166 0.87 TFPI (0.57) TFPIKDM1AOPRM1OPRK1NMUR2
SCHEMBL29356641 0.87 KDM1A (0.65) TFPIKDM1ANMUR2NMUR1
SCHEMBL29411143 0.87 APLNR (0.65) TFPIOPRM1OPRK1NMUR2NMUR1
SCHEMBL31295738 0.87 TFPI (0.64) TFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326746-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2025-10-23 — — US disclosed
CN-115515685-B EIF4E inhibitors and uses thereof 皮克医疗公司 2025-04-08 — — CN disclosed
US-12234231-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2025-02-25 — — US disclosed
US-12157732-B2 eIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2024-12-03 — — US disclosed
US-12157731-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2024-12-03 — — US disclosed
US-12030875-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2024-07-09 — — US disclosed
US-20240208961-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2024-06-27 — — US disclosed
CN-118019739-A EIF4E inhibitors and uses thereof 皮克医疗公司 2024-05-10 — — CN disclosed
EP-3846793-B1 EIF4E INHIBITORS AND USES THEREOF PIC THERAPEUTICS INC (US) 2024-01-24 — — EP disclosed
US-20230399322-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2023-12-14 — — US disclosed
US-11753403-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2023-09-12 — — US disclosed
US-20230150997-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2023-05-18 — — US disclosed
US-20230134932-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2023-05-04 — — US disclosed
CN-115515685-A EIF4E inhibitor and application thereof 皮克医疗公司 2022-12-23 — — CN disclosed
US-20220356178-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2022-11-10 — — US disclosed
US-20220089587-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2022-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12157732-B2 eIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-20250326746-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-20230399322-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-20230134932-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-12030875-B2 EIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 TFPI 1895/4885KDM1A 2380/4885CXCL8 4079/4885
US-20230150997-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-20240208961-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-12157731-B2 EIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-12234231-B2 EIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-11753403-B2 EIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885
US-20220089587-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EEF2K TFPI 2321/4885KDM1A 1965/4885CXCL8 3895/4885
US-20220356178-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 TFPI 962/4885KDM1A 2661/4885CXCL8 4074/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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