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Sugi Predict / Compounds / SCHEMBL29478323

SCHEMBL29478323

SCHEMBL29478323

CC(C)(C)OC(=O)N(Cc1cc2ccc([C@H]3C[C@@H](n4cc(Br)c5c(N)ncnc54)[C@@H]4OC(C)(C)O[C@@H]43)cc2[nH]1)CC12CC(F)(C1)C2

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 19/20 0.49
▸ METTL14 Q9HCE5 3/20 0.47
▸ PRMT5 O14744 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29478318 0.86 METTL3 (0.42) METTL3METTL14PRMT5
SCHEMBL24293763 0.81 METTL3 (0.39) METTL3METTL14PRMT5
SCHEMBL29478334 0.80 METTL3 (0.35) METTL3METTL14
SCHEMBL24293550 0.76 METTL3 (0.48) METTL3METTL14
SCHEMBL29478342 0.76 METTL3 (0.48) METTL3METTL14
SCHEMBL24293971 0.74 METTL3 (0.32) METTL3
SCHEMBL29478266 0.72 METTL3 (0.90) METTL3METTL14
SCHEMBL31617992 0.70 METTL3 (0.38) METTL3PRMT5
SCHEMBL25048829 0.69 METTL3 (0.37) METTL3
SCHEMBL24293547 0.68 METTL3 (0.40) METTL3METTL14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022074391-A1 COMPOUNDS INHIBITORS OF METTL3 STORM THERAPEUTICS LIMITED (GB) 2022-04-14 — — WO disclosed
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