Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | PDE5A | O76074 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | PDE1A | P54750 | 1/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 1/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 1/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 5/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29478480 | 1.00 | MAPT (1.00) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL1752920 | 1.00 | MAPT (1.00) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7912100 | 0.89 | MAPT (0.81) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7913391 | 0.89 | MAPT (0.81) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8025428 | 0.88 | ALDH1A1 (0.79) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7914878 | 0.88 | MAPT (0.79) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7918565 | 0.88 | KDR (0.81) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7918387 | 0.86 | MAPT (0.75) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8021598 | 0.85 | NPSR1 (0.79) | MAPTPDE5AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7913416 | 0.84 | NPSR1 (0.73) | MAPTPDE5AALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220087970-A1 | PREVENTION OF ANESTHETIC-INDUCED NEUROCOGNITIVE DYSFUNCTION | THE JOHNS HOPKINS UNIVERSTY | 2022-03-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220087970-A1 | PREVENTION OF ANESTHETIC-INDUCED NEUROCOGNITIVE DYSFUNCTION | PYGB, PRKG1, ACHE | MAPT 659/4885PDE5A 39/4885ALDH1A1 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.