Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27096449 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10TSHRGAA | |
| SCHEMBL31273396 | 0.95 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10TSHRGAA | |
| SCHEMBL31423110 | 0.92 | KDM4E (0.40) | KDM4EALDH1A1HSD17B10TSHRGAA | |
| SCHEMBL31273371 | 0.84 | DAO (0.37) | KDM4EALDH1A1HSD17B10TSHRGAA | |
| SCHEMBL31273139 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10GAASMYD3 | |
| SCHEMBL17226839 | 0.82 | MMP9 (0.47) | KDM4ETLR9TLR8MMP9PDE4B | |
| SCHEMBL31423089 | 0.82 | MAOB (0.51) | KDM4EALDH1A1HSD17B10TSHRGAA | |
| SCHEMBL31422768 | 0.81 | MAOB (0.53) | KDM4EALDH1A1HSD17B10TSHRGAA | |
| SCHEMBL31273321 | 0.80 | MMP9 (0.38) | KDM4EALDH1A1HSD17B10TSHRTLR9 | |
| SCHEMBL10330638 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025085233-A1 | NOVEL DERIVATIVES OF QUINOLINONES, AND COMPOSITIONS AND METHODS THEREOF | ENSEM THERAPEUTICS, INC. (US) | 2025-04-24 | — | — | WO | disclosed |
| CN-119101045-A | Nitrogen-containing heterocyclic compounds, and preparation method and application thereof | 上海宇道生物技术有限公司 | 2024-12-10 | — | — | CN | disclosed |
| EP-4232444-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |