Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 4/20 | 0.36 |
| ▸ | KDM4B | O94953 | 4/20 | 0.36 |
| ▸ | KDM5C | P41229 | 4/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567173 | 0.89 | LRRK2 (0.43) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL22736007 | 0.89 | LRRK2 (0.43) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL29568119 | 0.87 | JAK2 (0.35) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL29480520 | 0.83 | JAK1 (0.34) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL22736015 | 0.83 | JAK1 (0.34) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL22736280 | 0.82 | GRM4 (0.38) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL29480555 | 0.82 | GRM4 (0.38) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL22735993 | 0.79 | EGLN1 (0.37) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736006 | 0.79 | GRM4 (0.36) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL29480471 | 0.79 | EGLN1 (0.37) | GRM4AURKAAURKBINCENPTPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | claimed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |