Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 8/20 | 0.39 |
| ▸ | CDK8 | P49336 | 8/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4B | O94953 | 2/20 | 0.37 |
| ▸ | KDM5C | P41229 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567173 | 1.00 | LRRK2 (0.43) | LRRK2MAPK1CCNCCDK8CDK19 | |
| SCHEMBL29480516 | 0.89 | KDM4A (0.36) | LRRK2KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29568119 | 0.87 | JAK2 (0.35) | KDM4AKDM4BKDM5CKDM5BGRM4 | |
| SCHEMBL29480520 | 0.83 | JAK1 (0.34) | LRRK2KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736015 | 0.83 | JAK1 (0.34) | LRRK2KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22716765 | 0.82 | GRM4 (0.34) | MAPK1CCNCCDK8KDM4AKDM4B | |
| SCHEMBL29568500 | 0.82 | GRM4 (0.34) | MAPK1CCNCCDK8KDM4AKDM4B | |
| SCHEMBL22736280 | 0.82 | GRM4 (0.38) | MAPK1KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29480555 | 0.82 | GRM4 (0.38) | MAPK1KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736009 | 0.81 | MAPK1 (0.38) | LRRK2MAPK1CCNCCDK8KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |