Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 9/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735763 | 1.00 | GRM4 (0.38) | GRM4HDAC4HTR2BMTNR1AKCNH2 | |
| SCHEMBL29480670 | 0.85 | GRM4 (0.34) | GRM4HDAC4 | |
| SCHEMBL22735754 | 0.85 | GRM4 (0.34) | GRM4HDAC4 | |
| SCHEMBL29480654 | 0.82 | GRM4 (0.35) | GRM4HDAC4 | |
| SCHEMBL22736355 | 0.80 | MELK (0.33) | GRM4HDAC4KCNH2 | |
| SCHEMBL29480755 | 0.80 | MELK (0.33) | GRM4HDAC4KCNH2 | |
| SCHEMBL22735728 | 0.79 | GRM4 (0.36) | GRM4HDAC4 | |
| SCHEMBL29480712 | 0.79 | GRM4 (0.36) | GRM4HDAC4 | |
| SCHEMBL22735955 | 0.77 | MAP3K7 (0.37) | GRM4HDAC4 | |
| SCHEMBL29480769 | 0.77 | MAP3K7 (0.37) | GRM4HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |