Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30538783 | 0.87 | MEN1 (0.43) | ADORA2AADORA2BNPSR1HCAR3KDM4E | |
| SCHEMBL27158470 | 0.80 | ADORA2A (0.39) | ADORA2AADORA2BNPSR1HCAR3KDM4E | |
| SCHEMBL27157993 | 0.77 | ADORA2A (0.39) | ADORA2AADORA2BNPSR1HCAR3KDM4E | |
| SCHEMBL30538743 | 0.75 | KMT2A (0.42) | ADORA2AADORA2BKDM4EHPGDMEN1 | |
| SCHEMBL29480784 | 0.74 | APAF1 (0.39) | KDM4EHPGDCYP3A4MAPTMEN1 | |
| SCHEMBL9862988 | 0.72 | LMNA (0.49) | ADORA2AADORA2BKDM4EHPGDCYP1A2 | |
| SCHEMBL23530019 | 0.72 | CYP1A2 (0.50) | ADORA2AKDM4EHPGDCYP1A2MAPT | |
| SCHEMBL29549645 | 0.72 | CYP1A2 (0.50) | ADORA2AKDM4EHPGDCYP1A2MAPT | |
| SCHEMBL30686398 | 0.72 | GLP1R (0.40) | KDM4ECYP1A2CYP3A4MAPTMEN1 | |
| SCHEMBL27158625 | 0.70 | ADORA2A (0.38) | ADORA2AADORA2BKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204415-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022042691-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2022-03-03 | — | — | WO | disclosed |