Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276196 | 0.86 | GAA (0.59) | CNR1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4599304 | 0.85 | HSD11B1 (0.59) | SMN1; SMN2ALDH1A1HSD11B1TSHRKMT2A | |
| SCHEMBL7121916 | 0.83 | SMN1; SMN2 (0.77) | GAASMN1; SMN2ALDH1A1TSHRNPSR1 | |
| SCHEMBL3092100 | 0.83 | HSD11B1 (0.56) | CNR1ALDH1A1HSD11B1TSHRKMT2A | |
| SCHEMBL28812724 | 0.81 | RXFP1 (0.60) | ALDH1A1HSD11B1 | |
| SCHEMBL24363913 | 0.80 | CNR1 (0.54) | CNR1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL19657125 | 0.80 | CNR1 (0.54) | CNR1ALDH1A1TSHRTP53HTT | |
| SCHEMBL1447674 | 0.80 | KDM4E (0.63) | CNR1GAASMN1; SMN2TSHRKMT2A | |
| SCHEMBL30367909 | 0.79 | HSD11B1 (0.56) | CNR1SMN1; SMN2ALDH1A1HSD11B1TSHR | |
| (2-Aminophenyl)(Morpholino)Methanone SCHEMBL30988542 | 0.79 | GAA (0.62) | GAASMN1; SMN2ALDH1A1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-B1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH INC (US) | 2022-04-27 | — | — | EP | claimed |