SCHEMBL29484629

SCHEMBL29484629

CN1CCC[C@H]1COc1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 7/20 1.00
CHRNB1 P11230 6/20 1.00
CHRNB4 P30926 6/20 1.00
CHRNA3 P32297 6/20 1.00
CHRNB3 Q05901 6/20 1.00
CHRNA4 P43681 5/20 1.00
CHRNA1 P02708 1/20 1.00
CHRNA7 P36544 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7372710 1.00 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL12214039 1.00 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL676032 1.00 CHRNB2 (1.00) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL7839221 0.99 CHRNB2 (0.97) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL8435491 0.96 CHRNB2 (0.92) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL8438369 0.96 CHRNB2 (0.92) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
Hydrochloric Acid SCHEMBL7406679 0.94 CHRNB2 (0.90) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL13424978 0.93 CHRNA3 (0.86) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL905202 0.93 CHRNA3 (0.86) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3
SCHEMBL30820824 0.93 CHRNA3 (0.86) CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137689-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE INC (US) 2026-05-21 US disclosed
EP-3129065-B1 TARGETED DRUG DELIVERY THROUGH AFFINITY BASED LINKERS AKAMARA THERAPEUTICS INC (US) 2026-05-13 EP disclosed
EP-4281056-A1 COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION- RELATED DYSFUNCTION EXISTS Alto Neuroscience, Inc. (US) 2023-11-29 EP disclosed
US-11701429-B2 Targeted drug delivery through affinity based linkers Akamara Therapeutics, Inc. (US) 2023-07-18 US disclosed
WO-2022159629-A1 COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION- RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE, INC. (US) 2022-07-28 WO disclosed
US-20220226331-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE, INC. 2022-07-21 US disclosed
US-20220062252-A1 CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES OMEROS CORP (US) 2022-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137689-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS CHRNA5, CHRNA2, CHRNA4 CHRNB2 11/4885CHRNB1 34/4885CHRNB4 15/4885
US-11701429-B2 Targeted drug delivery through affinity based linkers ABCG2, FCGR2A, ABCB1 CHRNB2 2238/4885CHRNB1 1444/4885CHRNB4 2820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.