Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.50 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22748314 | 1.00 | LMNA (0.56) | LMNAALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL7982492 | 0.83 | NPC1 (0.60) | LMNAALDH1A1SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL22748948 | 0.81 | MASP2 (0.51) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL29485930 | 0.81 | MASP2 (0.51) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4879420 | 0.81 | POLB (0.57) | LMNAALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL8808160 | 0.79 | MAPT (0.55) | LMNAALDH1A1MAPTSMN1; SMN2PDE7A | |
| SCHEMBL15227790 | 0.78 | LMNA (0.55) | LMNAALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3591203 | 0.76 | ALDH1A1 (0.44) | LMNAALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL810907 | 0.76 | PARP10 (0.46) | LMNAALDH1A1MAPTMAPK1PDE7A | |
| SCHEMBL22748806 | 0.76 | CYP1A2 (0.47) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976185-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - Fondazione Istituto FIRC di Oncologia Molecolare (IT) | 2022-04-06 | — | — | EP | disclosed |