Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24164979 | 1.00 | DCTPP1 (0.42) | DCTPP1KIF18APTGDR2KMT2AMEN1 | |
| SCHEMBL24165289 | 0.84 | PTGDR2 (0.36) | DCTPP1KIF18APTGDR2KMT2AMEN1 | |
| SCHEMBL24165220 | 0.81 | BRD4 (0.39) | DCTPP1PTGDR2KMT2AMEN1RAB9A | |
| SCHEMBL30368149 | 0.81 | BRD4 (0.39) | DCTPP1PTGDR2KMT2AMEN1RAB9A | |
| SCHEMBL21490482 | 0.79 | HSD11B1 (0.40) | DCTPP1PTGDR2KMT2AMEN1VCAM1 | |
| SCHEMBL24165525 | 0.79 | DCTPP1 (0.39) | DCTPP1KIF18APTGDR2KMT2AMEN1 | |
| SCHEMBL2273205 | 0.78 | CYP2C19 (0.44) | DCTPP1KIF18AKMT2AMEN1VCAM1 | |
| SCHEMBL29428770 | 0.78 | CYP2C19 (0.44) | DCTPP1KIF18AKMT2AMEN1VCAM1 | |
| SCHEMBL31089880 | 0.76 | SRC (0.35) | DCTPP1PTGDR2ALDH1A1SRC | |
| SCHEMBL12384877 | 0.75 | DCTPP1 (0.42) | DCTPP1KIF18AKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4175719-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2023-05-10 | — | — | EP | disclosed |
| WO-2022046989-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |