Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24165220 | 1.00 | BRD4 (0.39) | BRD4PTGDR2KMT2AMEN1ALDH3A1 | |
| SCHEMBL29486806 | 0.81 | DCTPP1 (0.42) | PTGDR2KMT2AMEN1POLBDCTPP1 | |
| SCHEMBL24164979 | 0.81 | DCTPP1 (0.42) | PTGDR2KMT2AMEN1POLBDCTPP1 | |
| SCHEMBL24165289 | 0.79 | PTGDR2 (0.36) | PTGDR2KMT2AMEN1POLBMAPT | |
| SCHEMBL24165086 | 0.78 | BRD4 (0.37) | BRD4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL24165002 | 0.77 | MAPK1 (0.37) | BRD4PTGDR2MAPK1LRRK2 | |
| SCHEMBL29428761 | 0.71 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1CYP2C19GAA | |
| SCHEMBL31411153 | 0.69 | LRRK2 (0.55) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL30493927 | 0.69 | PTGDR2 (0.38) | PTGDR2KMT2AMEN1POLBMAPT | |
| SCHEMBL29181142 | 0.68 | HTT (0.50) | BRD4KMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4175719-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2023-05-10 | — | — | EP | disclosed |