Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.74 |
| ▸ | CHRNA1 | P02708 | 5/20 | 0.74 |
| ▸ | CHRNG | P07510 | 5/20 | 0.74 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.74 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.74 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.74 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.74 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.74 |
| ▸ | CHRND | Q07001 | 5/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.74 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955630 | 1.00 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL1226857 | 1.00 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL2955633 | 1.00 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL29564521 | 0.91 | CYP2B6 (0.83) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL15478523 | 0.89 | CYP2B6 (0.80) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL300444 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL12499296 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL29354885 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL38777 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL29424575 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025245375-A1 | USE OF BUPROPION AND DEXTROMETHORPHAN COMBINATIONS FOR TREATING NEUROLOGICAL DISORDERS | ANTECIP BIOVENTURES II LLC (US) | 2025-11-27 | — | — | WO | disclosed |
| EP-4593814-A1 | COMBINATION FOR USE IN A METHOD OF PREVENTING WEIGHT GAIN | Rose Research Center, LLC (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073334-A1 | COMBINATION FOR USE IN A METHOD OF PREVENTING WEIGHT GAIN | ROSE RESEARCH CENTER, LLC (US) | 2024-04-04 | — | — | WO | disclosed |
| EP-4337181-A1 | COMBINATION TREATMENT METHODS | Rose Research Center, LLC (US) | 2024-03-20 | — | — | EP | disclosed |
| CN-116981450-A | Combination of antidepressants and dextromethorphan for the treatment of neuropsychiatric disorders | 安泰赛普生物风投二代有限责任公司 | 2023-10-31 | — | — | CN | disclosed |
| US-20220411872-A1 | IN VITRO DRUG METABOLISM REAGENT AND USES THEREOF | IN VITRO ADMET LABORATORIES, LLC (US) | 2022-12-29 | — | — | US | disclosed |
| WO-2022240819-A1 | COMBINATION TREATMENT METHODS | ROSE RESEARCH CENTER, LLC (US) | 2022-11-17 | — | — | WO | disclosed |
| CN-114423417-A | Dosage forms and methods for enantiomerically enriched or pure bupropion | 艾克萨姆治疗公司 | 2022-04-29 | — | — | CN | disclosed |