Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.65 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.65 |
| ▸ | CHRNG | P07510 | 4/20 | 0.65 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.65 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.65 |
| ▸ | CHRND | Q07001 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955633 | 0.91 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL29486913 | 0.91 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL1226857 | 0.91 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL2955630 | 0.91 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL13416071 | 0.84 | SLC6A2 (0.81) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL15478523 | 0.83 | CYP2B6 (0.80) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL13001623 | 0.80 | CYP2B6 (0.74) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL38777 | 0.79 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL12499296 | 0.79 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL29424575 | 0.79 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119555831-A | Liquid chromatography mass spectrometry detection method for simultaneously measuring seven key probe substrate metabolites in CYP (CYP inhibition) inhibition test | 上海药明康德新药开发有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-114778747-B | Method for simultaneously detecting 16 drugs and metabolites thereof in blood by UPLC-MS/MS method | 北京和合医学诊断技术股份有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-114778747-A | Method for simultaneously detecting 16 drugs and metabolites thereof in blood by UPLC-MS/MS method | 北京和合医学诊断技术股份有限公司 | 2022-07-22 | — | — | CN | claimed |
| EP-3977138-A1 | DETERMINATION OF ANTIDEPRESSANTS BY MASS SPECTROMETRY | Quest Diagnostics Investments LLC (US) | 2022-04-06 | — | — | EP | claimed |
| US-12584111-B2 | Compositions and methods for long term culture of hepatocytes | PEKING UNIVERSITY (CN) | 2026-03-24 | — | — | US | disclosed |
| US-20250349528-A1 | DETERMINATION OF ANTIDEPRESSANTS BY MASS SPECTROMETRY | QUEST DIAGNOSTICS INVEST LLC (US) | 2025-11-13 | — | — | US | disclosed |
| US-12394612-B2 | Determination of antidepressants by mass spectrometry | QUEST DIAGNOSTICS INVESTMENTS LLC (US) | 2025-08-19 | — | — | US | disclosed |
| CN-114127554-B | Determination of antidepressants by mass spectrometry | 奎斯特诊断投资有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-119555831-A | Liquid chromatography mass spectrometry detection method for simultaneously measuring seven key probe substrate metabolites in CYP (CYP inhibition) inhibition test | 上海药明康德新药开发有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-118878511-A | Adamantane derivative, PROTAC degradation agent targeting ER, preparation method and application thereof | 晨伫(杭州)生物科技有限责任公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-118812505-A | PI5P4K gamma inhibitor compound, pharmaceutical composition, and preparation method and application thereof | 贵州医科大学 | 2024-10-22 | — | — | CN | disclosed |
| US-20240120188-A1 | DETERMINATION OF ANTIDEPRESSANTS BY MASS SPECTROMETRY | QUEST DIAGNOSTICS INVEST LLC (US) | 2024-04-11 | — | — | US | disclosed |
| US-11887828-B2 | Determination of antidepressants by mass spectrometry | QUEST DIAGNOSTICS INVESTMENTS LLC (US) | 2024-01-30 | — | — | US | disclosed |
| US-11613735-B2 | Methods for reprograming non-hepatocyte cells into hepatocyte cells | BEIHAO STEM CELL AND REGENERATIVE MEDICINE TRANSLATIONAL RESEARCH INSTITUTE (CN) | 2023-03-28 | — | — | US | disclosed |
| CN-114778747-B | Method for simultaneously detecting 16 drugs and metabolites thereof in blood by UPLC-MS/MS method | 北京和合医学诊断技术股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-114778747-A | Method for simultaneously detecting 16 drugs and metabolites thereof in blood by UPLC-MS/MS method | 北京和合医学诊断技术股份有限公司 | 2022-07-22 | — | — | CN | disclosed |
| US-20220135941-A1 | COMPOSITIONS AND METHODS FOR LONG TERM CULTURE OF HEPATOCYTES | PEKING UNIVERSITY (CN) | 2022-05-05 | — | — | US | disclosed |
| EP-3977138-A1 | DETERMINATION OF ANTIDEPRESSANTS BY MASS SPECTROMETRY | Quest Diagnostics Investments LLC (US) | 2022-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12584111-B2 | Compositions and methods for long term culture of hepatocytes | WNT3A, CTNNB1, WNT1 | CYP2B6 1213/4885SLC6A2 2272/4885SLC6A3 3642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.