Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.74 |
| ▸ | CHRNA1 | P02708 | 5/20 | 0.74 |
| ▸ | CHRNG | P07510 | 5/20 | 0.74 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.74 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.74 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.74 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.74 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.74 |
| ▸ | CHRND | Q07001 | 5/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.74 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1226857 | 1.00 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL29486913 | 1.00 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL2955633 | 1.00 | CYP2B6 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL29564521 | 0.91 | CYP2B6 (0.83) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| SCHEMBL15478523 | 0.89 | CYP2B6 (0.80) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL38777 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL29354885 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL29424575 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL300444 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG | |
| Bupropion SCHEMBL12499296 | 0.85 | SLC6A3 (1.00) | CYP2B6SLC6A2SLC6A3CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311727-A1 | THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS | ALGEBRA, INC. (US) | 2010-12-09 | — | — | US | claimed |
| US-7763612-B2 | Therapeutic amine-arylsulfonamide conjugate compounds | ALGEBRA, INC. (US) | 2010-07-27 | — | — | US | claimed |
| EP-1259243-B2 | BUPROPION METABOLITES AND METHODS OF THEIR SYNTHESIS AND USE | SEPRACOR INC (US) | 2010-07-21 | — | — | EP | claimed |
| US-20070155729-A1 | THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS | ALGEBRA, INC. (US) | 2007-07-05 | — | — | US | claimed |
| US-20100311727-A1 | THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS | ALGEBRA, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7763612-B2 | Therapeutic amine-arylsulfonamide conjugate compounds | ALGEBRA, INC. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20100125070-A1 | Bupropion Metabolites and Methods of Their Synthesis and Use | FANG KEVIN QUN | 2010-05-20 | — | — | US | disclosed |
| US-20070155729-A1 | THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS | ALGEBRA, INC. (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155729-A1 | THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS | AADAT, AADAC, AANAT | CYP2B6 105/4885SLC6A2 49/4885SLC6A3 21/4885 |
| US-20100125070-A1 | Bupropion Metabolites and Methods of Their Synthesis and Use | MAOB, MAOA, HTR5A | CYP2B6 104/4885SLC6A2 6/4885SLC6A3 10/4885 |
| US-20100311727-A1 | THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS | AADAT, AADAC, AANAT | CYP2B6 105/4885SLC6A2 49/4885SLC6A3 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.