Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | UBE2N | P61088 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862547 | 1.00 | POLB (0.49) | POLBSMN1; SMN2HTTLMNAUBE2N | |
| SCHEMBL22862639 | 0.89 | POLB (0.42) | POLBSMN1; SMN2HTTLMNAUBE2N | |
| SCHEMBL29490265 | 0.89 | POLB (0.42) | POLBSMN1; SMN2HTTLMNAUBE2N | |
| SCHEMBL22862548 | 0.84 | POLB (0.45) | POLBSMN1; SMN2HTTLMNAUBE2N | |
| SCHEMBL29490287 | 0.84 | POLB (0.45) | POLBSMN1; SMN2HTTLMNAUBE2N | |
| SCHEMBL22862467 | 0.83 | HTT (0.43) | POLBSMN1; SMN2HTTLMNAMAPK1 | |
| SCHEMBL22862544 | 0.83 | PDE2A (0.41) | POLBSMN1; SMN2HTTLMNAPDE2A | |
| SCHEMBL22862941 | 0.82 | CYP11B2 (0.38) | SMN1; SMN2HTTLMNAUBE2NL3MBTL1 | |
| SCHEMBL22862437 | 0.82 | CDK9 (0.40) | POLBSMN1; SMN2HTTLMNARAD52 | |
| SCHEMBL22862773 | 0.82 | CYP11B2 (0.38) | SMN1; SMN2HTTLMNAUBE2NL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |