Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24704178 | 1.00 | HDAC1 (0.35) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL22862947 | 0.86 | RAD52 (0.43) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL29490308 | 0.86 | RAD52 (0.43) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL29490176 | 0.84 | HDAC1 (0.35) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL22862466 | 0.84 | HDAC1 (0.35) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL22862481 | 0.84 | MAPT (0.35) | RAD52POLBMAPK1SMN1; SMN2 | |
| SCHEMBL22862467 | 0.77 | HTT (0.43) | DPP4HTTLMNAPOLBCYP11B2 | |
| SCHEMBL22862547 | 0.77 | POLB (0.49) | RAD52HTTLMNAPOLBMAPK1 | |
| SCHEMBL29490210 | 0.77 | POLB (0.49) | RAD52HTTLMNAPOLBMAPK1 | |
| SCHEMBL22862437 | 0.76 | CDK9 (0.40) | RAD52DPP4HTTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |