Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.45 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25366051 | 1.00 | DGAT1 (0.45) | DGAT1F2RL1ALOX5APFEN1NPC1 | |
| SCHEMBL31411454 | 0.87 | DGAT1 (0.38) | DGAT1F2RL1ALOX5APFEN1NPC1 | |
| SCHEMBL30536675 | 0.85 | DGAT1 (0.36) | DGAT1F2RL1ALOX5APFEN1NPC1 | |
| SCHEMBL31459865 | 0.85 | DGAT1 (0.36) | DGAT1F2RL1ALOX5APFEN1NPC1 | |
| SCHEMBL32671098 | 0.85 | DGAT1 (0.36) | DGAT1NPC1 | |
| SCHEMBL25367415 | 0.85 | DGAT1 (0.36) | DGAT1F2RL1ALOX5APFEN1NPC1 | |
| SCHEMBL30855733 | 0.82 | DGAT1 (0.39) | DGAT1F2RL1ALOX5APFEN1NPC1 | |
| SCHEMBL25366953 | 0.81 | DGAT1 (0.36) | DGAT1 | |
| SCHEMBL29493812 | 0.81 | DGAT1 (0.36) | DGAT1 | |
| SCHEMBL25368727 | 0.80 | DGAT1 (0.41) | DGAT1F2RL1ALOX5APFEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116600801-A | HSD17B13 inhibitors and uses thereof | FL2022-001公司 | 2023-08-15 | — | — | CN | disclosed |
| EP-4221701-A1 | HSD17B13 INHIBITORS AND USES THEREOF | FL2022-001, Inc. (US) | 2023-08-09 | — | — | EP | disclosed |
| WO-2022072491-A1 | HSD17B13 INHIBITORS AND USES THEREOF | METACRINE, INC. (US) | 2022-04-07 | — | — | WO | disclosed |