Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22969590 | 1.00 | CYP3A4 (0.54) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| SCHEMBL22969153 | 0.87 | TNF (0.54) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| SCHEMBL29495912 | 0.87 | TNF (0.54) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL29698800 | 0.86 | TNF (0.53) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| SCHEMBL6240424 | 0.82 | LMNA (0.63) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| SCHEMBL21222956 | 0.81 | DHFR (0.47) | CYP3A4LMNAKDM4EMEN1TP53 | |
| SCHEMBL22969139 | 0.80 | PRKCZ (0.56) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29495944 | 0.80 | PRKCZ (0.56) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL25454970 | 0.76 | LMNA (0.53) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| SCHEMBL2946765 | 0.75 | LMNA (0.51) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010328-A1 | 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Domain Therapeutics (FR) | 2022-06-15 | — | — | EP | claimed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | claimed |
| EP-4010328-A1 | 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Domain Therapeutics (FR) | 2022-06-15 | — | — | EP | disclosed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |