Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SHMT2 | P34897 | 8/20 | 0.46 |
| ▸ | ATR | Q13535 | 2/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28722024 | 1.00 | GAA (0.55) | GAASHMT2ATRATRIPPIM1 | |
| SCHEMBL29495968 | 0.94 | GAA (0.50) | GAASHMT2ATRATRIPPIM1 | |
| SCHEMBL29496047 | 0.84 | SHMT2 (0.43) | GAASHMT2PIM1SMN1; SMN2 | |
| SCHEMBL28722897 | 0.84 | SHMT2 (0.43) | GAASHMT2PIM1SMN1; SMN2 | |
| SCHEMBL30718774 | 0.79 | SHMT2 (0.56) | GAASHMT2ATRATRIPPIM1 | |
| SCHEMBL27140115 | 0.79 | SHMT2 (0.56) | GAASHMT2ATRATRIPPIM1 | |
| SCHEMBL1134096 | 0.79 | NPC1 (0.48) | GAAPIM1CNR2SMN1; SMN2KMT2A | |
| SCHEMBL28722866 | 0.77 | GAA (0.68) | GAAATRATRIPPIM1CCNC | |
| SCHEMBL29495981 | 0.77 | GAA (0.68) | GAAATRATRIPPIM1CCNC | |
| SCHEMBL29496154 | 0.75 | MAP3K12 (0.34) | GAASHMT2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |