Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28722024 | 0.75 | GAA (0.55) | SHMT2GAAKMT2A | |
| SCHEMBL29496103 | 0.75 | GAA (0.55) | SHMT2GAAKMT2A | |
| SCHEMBL29496047 | 0.75 | SHMT2 (0.43) | SHMT2GAA | |
| SCHEMBL28722897 | 0.75 | SHMT2 (0.43) | SHMT2GAA | |
| SCHEMBL29495870 | 0.71 | REN (0.32) | MAP3K12MTORPIK3CAPIK3R1 | |
| SCHEMBL22969281 | 0.71 | REN (0.32) | MAP3K12MTORPIK3CAPIK3R1 | |
| SCHEMBL29495968 | 0.71 | GAA (0.50) | SHMT2GAA | |
| SCHEMBL29496133 | 0.71 | MAP3K12 (0.31) | MAP3K12MTOR | |
| SCHEMBL16125192 | 0.70 | BACE1 (0.41) | GAA | |
| SCHEMBL21162698 | 0.68 | KMT2A (0.41) | MAP3K12MTORPIK3CALRRK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010328-A1 | 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Domain Therapeutics (FR) | 2022-06-15 | — | — | EP | disclosed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |