Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27140115 | 1.00 | SHMT2 (0.56) | SHMT2SMN1; SMN2KMT2ARAB9AKDM4E | |
| SCHEMBL30718760 | 0.80 | SHMT2 (0.53) | SHMT2SMN1; SMN2RAB9AKDM4EGAA | |
| SCHEMBL27143319 | 0.80 | SHMT2 (0.53) | SHMT2SMN1; SMN2RAB9AKDM4EGAA | |
| SCHEMBL30718849 | 0.80 | SHMT2 (0.56) | SHMT2SMN1; SMN2RAB9AGAAATR | |
| SCHEMBL27143890 | 0.80 | SHMT2 (0.56) | SHMT2SMN1; SMN2RAB9AGAAATR | |
| SCHEMBL28722024 | 0.79 | GAA (0.55) | SHMT2SMN1; SMN2KMT2AGAAATR | |
| SCHEMBL29496103 | 0.79 | GAA (0.55) | SHMT2SMN1; SMN2KMT2AGAAATR | |
| SCHEMBL1500149 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2ARAB9AKDM4EMEN1 | |
| SCHEMBL27320681 | 0.77 | SHMT2 (0.53) | SHMT2SMN1; SMN2KMT2AGAAATR | |
| SCHEMBL21588490 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2ARAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547658-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | Bristol-Myers Squibb Company (US) | 2025-05-07 | — | — | EP | disclosed |
| CN-119325469-A | WEE1 degrading compounds and uses thereof | 百时美施贵宝公司 | 2025-01-17 | — | — | CN | disclosed |
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |