Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
| ▸ | SNCA | P37840 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | HBB | P68871 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | MAT2A | P31153 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949632 | 1.00 | APP (1.00) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL14895393 | 0.80 | APP (0.67) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL2776332 | 0.80 | APP (0.67) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL2776337 | 0.80 | APP (0.67) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL700192 | 0.79 | APP (0.65) | APPRELAMAOAMAOB | |
| SCHEMBL700193 | 0.79 | APP (0.65) | APPRELAMAOAMAOB | |
| SCHEMBL7944755 | 0.79 | APP (0.65) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL29403616 | 0.79 | MAT2A (0.67) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL2487914 | 0.79 | APP (0.65) | APPRELASNCAMEN1KMT2A | |
| SCHEMBL7944752 | 0.79 | APP (0.65) | APPRELASNCAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432453-B1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2013-08-14 | — | — | EP | disclosed |
| US-7759502-B2 | Useful for inhibiting the aggregation of amyloid protein to form amyloid deposit | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-07-20 | — | — | US | disclosed |
| US-20080108840-A1 | Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2008-05-08 | — | — | US | disclosed |
| US-7297820-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-11-20 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-7250525-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-31 | — | — | US | disclosed |
| EP-1432453-A4 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20060002853-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-01-05 | — | — | US | disclosed |
| EP-1432453-A1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees of The University of Pennsylvania (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20030149250-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-08-07 | — | — | US | disclosed |
| WO-2003018070-A1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060002853-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885RELA 2968/4885SNCA 46/4885 |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | APP 1/4885RELA 2689/4885SNCA 165/4885 |
| US-20080108840-A1 | Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques | APP, APBA1, PSEN1 | APP 1/4885RELA 2968/4885SNCA 46/4885 |
| US-20030149250-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885RELA 2968/4885SNCA 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.