Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 10/20 | 1.00 |
| ▸ | NOD2 | Q9HC29 | 10/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 7/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.84 |
| ▸ | WEE1 | P30291 | 5/20 | 0.84 |
| ▸ | SRC | P12931 | 4/20 | 0.84 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.84 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.84 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.84 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.84 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.84 |
| ▸ | JAK2 | O60674 | 1/20 | 0.84 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.84 |
| ▸ | PAK4 | O96013 | 1/20 | 0.84 |
| ▸ | ABL1 | P00519 | 1/20 | 0.84 |
| ▸ | EGFR | P00533 | 1/20 | 0.84 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.84 |
| ▸ | LCK | P06239 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20563458 | 1.00 | RIPK2 (1.00) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| Pd-0166285 SCHEMBL30250248 | 0.92 | FGFR1 (1.00) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| Pd-0166285 SCHEMBL133914 | 0.92 | FGFR1 (1.00) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| Pd-0166285 SCHEMBL30276696 | 0.91 | FGFR1 (0.98) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| SCHEMBL20564619 | 0.91 | RIPK2 (1.00) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| Pd-0166285 SCHEMBL15106017 | 0.91 | FGFR1 (0.98) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| SCHEMBL29498180 | 0.91 | RIPK2 (1.00) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| Pd-0166285 SCHEMBL29658286 | 0.90 | FGFR1 (0.97) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| Pd-0166285 SCHEMBL15923205 | 0.90 | FGFR1 (0.97) | RIPK2NOD2ACVR1FGFR1WEE1 | |
| SCHEMBL20563994 | 0.89 | RIPK2 (1.00) | RIPK2NOD2ACVR1FGFR1WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3968991-A1 | PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS | University of Houston System (US) | 2022-03-23 | — | — | EP | disclosed |