Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pd-0166285. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 known ✓ | P11362 | 9/20 | 1.00 |
| ▸ | SRC known ✓ | P12931 | 6/20 | 1.00 |
| ▸ | PDGFRB known ✓ | P09619 | 3/20 | 1.00 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 1.00 |
| ▸ | RIPK2 | O43353 | 8/20 | 1.00 |
| ▸ | NOD2 | Q9HC29 | 8/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 7/20 | 1.00 |
| ▸ | WEE1 | P30291 | 4/20 | 1.00 |
| ▸ | PDGFRA | P16234 | 3/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 2/20 | 1.00 |
| ▸ | FGFR4 | P22455 | 2/20 | 1.00 |
| ▸ | FGFR3 | P22607 | 2/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 1/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 1/20 | 1.00 |
| ▸ | PAK4 | O96013 | 1/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 1/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pd-0166285 SCHEMBL133914 | 1.00 | FGFR1 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL15106017 | 0.99 | FGFR1 (0.98) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL30276696 | 0.99 | FGFR1 (0.98) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL15923205 | 0.98 | FGFR1 (0.97) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL29658286 | 0.98 | FGFR1 (0.97) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL10108147 | 0.95 | FGFR1 (0.91) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL10108496 | 0.94 | FGFR1 (0.89) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL20563458 | 0.92 | RIPK2 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL29498246 | 0.92 | RIPK2 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL10102543 | 0.90 | FGFR1 (0.86) | FGFR1RIPK2NOD2ACVR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4127722-A2 | METHODS AND COMPOSITIONS FOR TREATING CANCER | Engine Biosciences Pte. Ltd. (SG) | 2023-02-08 | — | — | EP | claimed |
| WO-2025101691-A1 | METHODS FOR TREATING CANCER USING COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2025-05-15 | — | — | WO | disclosed |
| EP-3914698-B1 | CULTURE MEDIA FOR PLURIPOTENT STEM CELLS | YEDA RES & DEV (IL) | 2024-12-11 | — | — | EP | disclosed |
| US-20240318144-A1 | MEDIA FOR CULTURING NAIVE HUMAN PLURIPOTENT STEM CELLS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2024-09-26 | — | — | US | disclosed |
| EP-3194572-B1 | MEDIA FOR CULTURING PLURIPOTENT STEM CELLS | YEDA RES & DEV (IL) | 2023-10-25 | — | — | EP | disclosed |
| WO-2023166080-A1 | COMBINATION TREATMENTS COMPRISING A CTPS1 INHIBITOR AND A WEE1 INHIBITOR | STEP PHARMA S.A.S. (FR) | 2023-09-07 | — | — | WO | disclosed |
| EP-4127722-A2 | METHODS AND COMPOSITIONS FOR TREATING CANCER | Engine Biosciences Pte. Ltd. (SG) | 2023-02-08 | — | — | EP | disclosed |