Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pd-0166285. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 known ✓ | P11362 | 9/20 | 0.97 |
| ▸ | SRC known ✓ | P12931 | 6/20 | 0.97 |
| ▸ | PDGFRB known ✓ | P09619 | 3/20 | 0.97 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.97 |
| ▸ | RIPK2 | O43353 | 8/20 | 0.97 |
| ▸ | NOD2 | Q9HC29 | 8/20 | 0.97 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.97 |
| ▸ | WEE1 | P30291 | 4/20 | 0.97 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.97 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.97 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.97 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.97 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.97 |
| ▸ | JAK2 | O60674 | 1/20 | 0.97 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.97 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.97 |
| ▸ | PAK4 | O96013 | 1/20 | 0.97 |
| ▸ | ABL1 | P00519 | 1/20 | 0.97 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.97 |
| ▸ | LCK | P06239 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pd-0166285 SCHEMBL15923205 | 1.00 | FGFR1 (0.97) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL15106017 | 0.99 | FGFR1 (0.98) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL30276696 | 0.99 | FGFR1 (0.98) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL133914 | 0.98 | FGFR1 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| Pd-0166285 SCHEMBL30250248 | 0.98 | FGFR1 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL10108147 | 0.94 | FGFR1 (0.91) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL10108496 | 0.93 | FGFR1 (0.89) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL20563458 | 0.90 | RIPK2 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| SCHEMBL29498246 | 0.90 | RIPK2 (1.00) | FGFR1RIPK2NOD2ACVR1SRC | |
| Hydrochloric Acid SCHEMBL5763427 | 0.89 | FGFR1 (0.81) | FGFR1RIPK2NOD2ACVR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103678-A1 | BILAYER OF RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTORS AND USE THEREOF | FUJIFILM Cellular Dynamics, Inc. (US) | 2026-04-16 | — | — | US | disclosed |
| EP-4680255-A1 | METHODS FOR PRODUCING STABLE HUMAN CHONDROCTYES AND THEIR USE FOR PROMOTING CARTILLAGE GROWTH AND REPAIR | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2026-01-21 | — | — | EP | disclosed |
| WO-2024192329-A1 | METHODS FOR PRODUCING STABLE HUMAN CHONDROCTYES AND THEIR USE FOR PROMOTING CARTILLAGE GROWTH AND REPAIR | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2024-09-19 | — | — | WO | disclosed |
| EP-4347795-A1 | METHODS TO GENERATE MACULAR, CENTRAL AND PERIPHERAL RETINAL PIGMENT EPITHELIAL CELLS | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2024-04-10 | — | — | EP | disclosed |
| EP-4346928-A1 | BIODEGRADABLE TISSUE SCAFFOLD WITH SECONDARY MATRIX TO HOST WEAKLY ADHERENT CELLS | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2024-04-10 | — | — | EP | disclosed |
| US-20230212509-A1 | BILAYER OF RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTORS AND USE THEREOF | FUJIFILM Cellular Dynamics, Inc. (US) | 2023-07-06 | — | — | US | disclosed |
| CN-116323677-A | Retinal pigment epithelium and photoreceptor bilayer and uses thereof | 富士胶片细胞动力公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116033912-A | Retinal pigment epithelium and photoreceptor double cell aggregates and methods of use thereof | 富士胶片细胞动力公司 | 2023-04-28 | — | — | CN | disclosed |
| EP-4157294-A1 | RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTOR DUAL CELL AGGREGATES AND METHODS OF USE THEREOF | FUJIFILM Cellular Dynamics, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| EP-4157865-A1 | BILAYER OF RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTORS AND USE THEREOF | FUJIFILM Cellular Dynamics, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| WO-2022251477-A1 | BIODEGRADABLE TISSUE SCAFFOLD WITH SECONDARY MATRIX TO HOST WEAKLY ADHERENT CELLS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-12-01 | — | — | WO | disclosed |
| WO-2022251499-A1 | METHODS TO GENERATE MACULAR, CENTRAL AND PERIPHERAL RETINAL PIGMENT EPITHELIAL CELLS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-12-01 | — | — | WO | disclosed |
| EP-4001402-A1 | MACS-BASED PURIFICATION OF STEM CELL-DERIVED RETINAL PIGMENT EPITHELIUM | FUJIFILM Cellular Dynamics, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103678-A1 | BILAYER OF RETINAL PIGMENTED EPITHELIUM AND PHOTORECEPTORS AND USE THEREOF | PAX2, ZP1, ALDH1A2 | FGFR1 712/4885SRC 3358/4885PDGFRB 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.