Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946246 | 0.87 | ESR1 (0.63) | ESR1ESR2ALDH1A1ARVDR | |
| SCHEMBL12588047 | 0.82 | ESR1 (1.00) | ESR1ESR2ARKLF10BACE1 | |
| SCHEMBL2943056 | 0.77 | VDR (0.59) | ARVDR | |
| SCHEMBL6015264 | 0.76 | ESR1 (0.80) | ESR1ESR2ALDH1A1ARKDM4E | |
| SCHEMBL13203735 | 0.74 | ESR1 (0.59) | ESR1ESR2ARCA1CA2 | |
| SCHEMBL2943406 | 0.73 | ESR1 (0.63) | ESR1ESR2ARVDR | |
| SCHEMBL14513106 | 0.73 | ALDH1A1 (0.43) | ESR1ESR2ALDH1A1ARKDM4E | |
| SCHEMBL13264815 | 0.73 | SRD5A1 (0.35) | ESR1ESR2ALDH1A1ARKDM4E | |
| SCHEMBL13264569 | 0.71 | SRD5A1 (0.36) | ESR1ESR2ALDH1A1ARKDM4E | |
| SCHEMBL13264818 | 0.71 | VDR (0.36) | ESR1ESR2ALDH1A1ARKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750184-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750184-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750184-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2010-07-06 | — | — | US | disclosed |
| US-20060293385-A1 | Vitamin d receptor modulators | ELI LILLY AND COMPANY, AN INDIANA CORPORATION | 2006-12-28 | — | — | US | disclosed |
| EP-1687265-A2 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005051898-A2 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293385-A1 | Vitamin d receptor modulators | VDR, CYP24A1, CYP2R1 | ESR1 186/4885ESR2 163/4885ALDH1A1 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.