Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22613886 | 1.00 | EGLN2 (0.34) | EGLN2KMOPDE4ATDO2PTGS1 | |
| SCHEMBL22613938 | 0.81 | NOTUM (0.45) | TDO2 | |
| SCHEMBL20722096 | 0.78 | NOTUM (0.37) | KMO | |
| SCHEMBL22614599 | 0.77 | KMO (0.33) | EGLN2KMOPDE4ATDO2 | |
| SCHEMBL29499463 | 0.77 | KMO (0.33) | EGLN2KMOPDE4ATDO2 | |
| SCHEMBL29408927 | 0.74 | HSD11B1 (0.38) | — | |
| SCHEMBL22613838 | 0.74 | HSD11B1 (0.38) | — | |
| SCHEMBL19556361 | 0.68 | ATF4 (0.43) | — | |
| SCHEMBL22614397 | 0.65 | KMO (0.39) | EGLN2KMO | |
| SCHEMBL22614230 | 0.65 | HRH3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206848-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-03-18 | — | — | CN | disclosed |