Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 10/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744926 | 1.00 | PLK4 (0.51) | PLK4MAPK1MAPK3LCKMAPK14 | |
| SCHEMBL28744911 | 0.83 | PLK4 (0.48) | PLK4MAPK1MAPK3HRH4CDK1 | |
| SCHEMBL29499597 | 0.83 | PLK4 (0.48) | PLK4MAPK1MAPK3HRH4CDK1 | |
| SCHEMBL28744841 | 0.79 | MAPK1 (0.56) | PLK4MAPK1MAPK3 | |
| SCHEMBL29499572 | 0.79 | MAPK1 (0.56) | PLK4MAPK1MAPK3 | |
| SCHEMBL29499586 | 0.78 | MAPK1 (0.50) | PLK4MAPK1MAPK3LCKMAPK14 | |
| SCHEMBL28744909 | 0.78 | MAPK1 (0.50) | PLK4MAPK1MAPK3LCKMAPK14 | |
| SCHEMBL13169984 | 0.75 | PLK4 (0.66) | PLK4MAPK8MAPK9MAPK10CDK2 | |
| SCHEMBL22729058 | 0.74 | MAPK1 (0.66) | MAPK1MAPK3LCKMAPK14MAPK8 | |
| SCHEMBL24710348 | 0.73 | MAPK1 (0.64) | MAPK1MAPK3LCKMAPK14MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276331-B | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114276331-A | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2022-04-05 | — | — | CN | disclosed |