Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | DGKZ | Q13574 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23039998 | 1.00 | GPR55 (0.46) | GPR55MEN1KMT2ADDB1CRBN | |
| SCHEMBL12026651 | 0.87 | MEN1 (0.51) | GPR55MEN1KMT2ADDB1CRBN | |
| SCHEMBL30912132 | 0.84 | KCNJ1 (0.47) | GPR55MEN1KMT2ADDB1CRBN | |
| SCHEMBL23040019 | 0.84 | KCNJ1 (0.47) | GPR55MEN1KMT2ADDB1CRBN | |
| SCHEMBL14565147 | 0.78 | IDO1 (0.52) | GPR55MEN1KMT2AKCNJ1IDO1 | |
| SCHEMBL5544722 | 0.76 | IDO1 (0.57) | IDO1ALDH1A1IDH1PKMTSHR | |
| SCHEMBL30537998 | 0.76 | IDO1 (0.57) | IDO1ALDH1A1IDH1PKMTSHR | |
| SCHEMBL14565146 | 0.76 | ALDH1A1 (0.47) | GPR55DDB1CRBNKCNJ1IDO1 | |
| SCHEMBL13183732 | 0.76 | CYP11B2 (0.58) | GPR55MEN1KMT2ADDB1CRBN | |
| SCHEMBL434086 | 0.74 | MIF (0.54) | MEN1KMT2AALDH1A1PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302884-B | Substituted pyridopyrimidinone compounds useful as T cell activators | 百时美施贵宝公司 | 2024-06-04 | — | — | CN | disclosed |
| EP-4021901-A1 | SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | Bristol-Myers Squibb Company (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-114302884-A | Substituted pyridopyrimidinone based compounds useful as T cell activators | 百时美施贵宝公司 | 2022-04-08 | — | — | CN | disclosed |