Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 7/20 | 0.42 |
| ▸ | NOS1 | P29475 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22549439 | 1.00 | NSD2 (0.42) | NSD2NOS2NOS1NOS3MAPT | |
| SCHEMBL22418701 | 0.88 | NOS1 (0.41) | NSD2NOS2NOS1NOS3MAPT | |
| SCHEMBL23304536 | 0.88 | FLT3 (0.41) | PRMT5WDR77SYK | |
| SCHEMBL30000062 | 0.87 | NSD2 (0.43) | NSD2NOS2NOS1NOS3MAPT | |
| SCHEMBL25389761 | 0.87 | NSD2 (0.45) | NSD2NOS2NOS1NOS3MAPT | |
| SCHEMBL25388838 | 0.87 | NSD2 (0.43) | NSD2NOS2NOS1NOS3MAPT | |
| SCHEMBL30000717 | 0.87 | NSD2 (0.45) | NSD2NOS2NOS1NOS3MAPT | |
| Hydrochloric Acid SCHEMBL25387169 | 0.87 | NOS1 (0.40) | NSD2NOS2NOS1NOS3MAPT | |
| Hydrochloric Acid SCHEMBL29501501 | 0.87 | NOS1 (0.40) | NSD2NOS2NOS1NOS3MAPT | |
| SCHEMBL1748149 | 0.85 | ALDH1A1 (0.51) | NSD2NOS2NOS1MAPTDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110621675-B | Tricyclic compounds useful for the treatment of proliferative diseases | 阿古诺治疗有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-116113626-A | Compound with anti-tumor activity and application thereof | 上海翊石医药科技有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-115340528-A | Compound with anti-tumor activity and application thereof | 上海翊石医药科技有限公司 | 2022-11-15 | — | — | CN | disclosed |
| WO-2022048631-A1 | COMPOUND HAVING ANTITUMOR ACTIVITY AND USE THEREOF | 上海翊石医药科技有限公司 | 2022-03-10 | — | — | WO | disclosed |