Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22835866 | 1.00 | ERN1 (0.56) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL30412897 | 0.85 | ALDH1A1 (0.55) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL5610655 | 0.85 | ALOX15 (0.55) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL2721914 | 0.83 | ALDH1A1 (0.53) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL16838199 | 0.83 | ALDH5A1 (0.55) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL16838200 | 0.83 | ERN1 (0.55) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL16838214 | 0.79 | ALDH5A1 (0.55) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL14691657 | 0.79 | CA12 (0.48) | ALDH1A1KDM4ECYP3A4MAPTALOX15 | |
| SCHEMBL15686380 | 0.79 | ALDH1A1 (0.53) | ERN1ALDH1A1KDM4ECYP3A4MAPT | |
| SCHEMBL1999504 | 0.79 | MAPT (0.49) | ERN1ALDH1A1KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367113-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | Biogen MA Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023283610-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |
| EP-3989966-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |